EMERGENCE OF NOVEL METHICILLIN RESISTANT STAPHYLOCOCCUS PSEUDINTERMEDIUS LINEAGES REVEALED BY WHOLE GENOME SEQUENCING OF ISOLATES FROM COMPANION ANIMALS AND HUMANS IN SCOTLAND.

Emergence of novel methicillin resistant Staphylococcus pseudintermedius lineages revealed by whole genome sequencing of isolates from companion animals and humans in Scotland.

Staphylococcus pseudintermedius is an opportunistic pathogen in dogs, and infection in humans is increasingly found, often linked to contact with dogs.We conducted a retrospective genotyping and antimicrobial susceptibility testing study of 406 S.pseudintermedius isolates cultured from animals (dogs, cats and an otter) and humans across Scotland, f

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Effect of Calcium ion on synaptotagmin-like protein during pre-fusion of vesicle for exocytosis in blood-brain barrier

Background: Calcium signaling Protection and membrane fusion play key roles in exocytosis of drug-containing vesicles through the blood-brain barrier (BBB).Identifying the role of synaptotagmin-like protein4-a (Slp4-a) in the presence of Ca2+ ions, at the pre-fusion stage of a vesicle with the basolateral membrane of endothelial cell, can reveal br

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